Nucleotides: At the Center of Immunity

7 min read /
Gastroenterology General Medicine Immunology Paediatrics Public Health Public health
Nucleotides: At the Center of Immunity

Exogenous nucleotides have been found to enhance immunity by providing benefits to immune cells and cells of the gastrointestinal tract.


1Hall, J., 2010 Guyton and Hall Textbook of Medical Physiology 12th ed USA. Saunders.
2Thompson, J.,, 2011. The Science of Nutrition 2nd ed. Pearson Education, Inc. USA. 
3Cilla, A.,, 2012. Prebiotics and nucleotides in infant feeding; Review of the Evidence. Nutricion Hospitalaria. vol.27 n.4 Jul./Aug. 2012
4Che L, Hu L, Liu Y, Yan C, Peng X, Xu Q, et al. (2016) Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model. PLoS ONE 11(6):e0157314.doi:10.1371/journal.pone.0157314.
5Gutie´rrez-Castrello´n, P, et. al., 2007) Immune response to nucleotide-supplemented infant formulae: systematic review and meta-analysis. British Journal of Nutrition 98, Suppl. 1, S64–S67 doi:10.1017/S000711450783296X.
6Carver, J., 2003. Advances in nutritional modifications of infant formulas American Journal of Clinical Nutrition 2003;77(s):1550S–4S. ,
7Eckhard Schlimme, E., et. al., 2000. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. British Journal of Nutrition, 84:S1, S59±S68.
8Lerner, A. & Shamir, R., 2000. Nucleotides in Infant Nutrition: A Must or an Option. IMAJ;2:772–774.
9Gil, A., (2002). Modulation of the immune response mediated by dietary nucleotides. European Journal of Clinical Nutrition 56(3),S1–S4. doi:10.1038=sj.ejcn.1601475 (journal review).
10Singha, A,, 2008, Dietary Nucleotides and Fecal Microbiota in Formula-Fed Infants: A Randomized Controlled Trial. Am J Clin Nutr 2008;87:1785–92 DOI:10.1093/ajcn/87.6.1785Lerner, A. & Shamir, M. 2000. Nucleotides in Infant Nutrition: A Must or an Option. Istrael Medical Association Journal  2000;2:772–774.
11Riva, E., 2005, Closer to the Gold Standard: an Appraisal of Formulae Available in Italy for Use in Formula-fed. Infants The Journal of International Medical Research 33: 595 – 611. DOI:10.1177/147323000503300601.
12Pickering, L., 1998.  Modulation of the Immune System by Human Milk and Infant Formula Containing Nucleotides. Pediatrics 101:242–249.
13Parham, P. 2015 The Immune System 4th ed. Garland Science, Taylor & Francis Group, LLC USA.
14Cruse, J and Lewis R., 2010. Altas of Immunology 3rd ed. CRC Press, USA.


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